Berberine enhances Ucp1 expression via modulating the NFE2 response element in cold environments: new perspectives on the thermogenesis in brown adipose tissue
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منابع مشابه
UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-/- mice.
Apart from UCP1-based nonshivering thermogenesis in brown adipocytes, the identity of thermogenic mechanisms that can be activated to reduce a positive energy balance is largely unknown. To identify potentially useful mechanisms, we have analyzed physiological and molecular mechanisms that enable mice, genetically deficient in UCP1 and sensitive to acute exposure to the cold at 4 degrees C, to ...
متن کاملBrown adipose tissue thermogenesis in neonatal and cold-adapted animals.
25 1-268 Seydoux, J., Trimble, E. R., Bouillaud, F., Assimacopoulos-Jeannet, F., Bas, S., Ricquier, D., Giacobino, J. P. & Girardier, L. (1984) FEBS Lett. 166, 141-145 Shibata, H. & Nagasaka, T. (1984) Jap. J. Physiol. 34, 103-1 11 Sundin, ‘U. & Fain, J. N. (1983) Biochem. Pharmacol. 32, 3117-3120 Sundin, U., Mills, I. & Fain, J. N. (1984) Metabolism 33, 1028-1033 Szillat, D. & Bukowiecki, L. J...
متن کاملThermogenesis of Brown Adipose Tissue in Cold-acclimated Rats.
SMITH, ROBERT E., AND JANE C. ROBERTS. Thermogenesis of brown ad ipose tissue in cold-acclimated rats. Am. J. Physiol. 206( I > : 143-148. I g64.-Multilocular brown adipose tissue in the rat is shown to increase in both mass and respiratory rate, in vitro, during cold acclimation. By vascular convection the resulting heat is directly applied to the thoracocervical regions of the spinal cord, th...
متن کاملCold-induced changes in gene expression in brown adipose tissue: implications for the activation of thermogenesis.
Brown adipose tissue (BAT) is the site of heat production (thermogenesis). This unique function is performed by uncoupling protein 1 (UCP1) specifically expressed in mitochondria of BAT. UCP1 dissipates the driving force of ATP synthesis, and thus causes heat production followed by energy expenditure. The thermogenic function of BAT has the role of maintaining body temperature under cold condit...
متن کاملBrown adipose tissue and thermogenesis.
The growing understanding of adipose tissue as an important endocrine organ with multiple metabolic functions has directed the attention to the (patho)physiology of distinct fat depots. Brown adipose tissue (BAT), in contrast to bona fide white fat, can dissipate significant amounts of chemical energy through uncoupled respiration and heat production (thermogenesis). This process is mediated by...
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ژورنال
عنوان ژورنال: Journal Of Chinese Pharmaceutical Sciences
سال: 2017
ISSN: 1003-1057
DOI: 10.5246/jcps.2017.04.025